Thickening and hardening of footpads resulting from abnormal proliferation of epidermal cells
Symptoms Horny protrusions on all footpads, fissures and cracks possibly causing great pain and therefore reduced mobility of the dog.
Gene involved FAM83G
Mutation tested c.155G>C
Transmission mode : Autosomal recessive
Publication : Drögemüller et al. (2014). A mutation in the FAM83G gene in dogs with hereditary footpad hyperkeratosis (HFH).
Gene involved KRT16
Mutation tested p.Glu392*
Transmission mode : Autosomal recessive
Publication : Plassais et al. (2015). A spontaneous KRT16 mutation in a dog breed: a model for human focal non-epidermolytic palmoplantar keratoderma (FNEPPK).
Gene involved DSG1
Mutation tested c.2541_2545delGGGCT
Transmission mode : Autosomal recessive
Publication : Backel et al. (2020). A DSG1 frameshift variant in a Rottweiler dog with footpad hyperkeratosis.