Hypopigmentation of the hair, skin and eyes
Symptoms
One or two blue eyes or particolored eyes and minimal white spotting.
Homozygous and compound heterozygous cats are white or almost-white and not viable or with high risk of deafness.
Gene involved PAX3
Mutation tested g.206975776_206975777insN[433] (DBEALT)
Transmission mode : Autosomal dominant Age of onset : From birth Specificity : Heterozygous state of this allele does not appear to be associated with deafness. Homozygous cats are viable but are at high risk of deafness.
Publication : Abitbol et al. (2024). Different founding effects underlie dominant blue eyes (DBE) in the domestic cat.
Gene involved PAX3
Mutation tested g.206974029_206974030insN[395] (DBECEL)
Transmission mode : Autosomal dominant Age of onset : From birth Specificity : Heterozygous state of this allele does not appear to be associated with deafness. Homozygous state is likely lethal.
Publication : Abitbol et al. (2024). A PAX3 insertion in the Celestial breed and certain feline breeding lines with dominant blue eyes.