Degenerative disease of the spinal cord causing progressive paralysis
Symptoms
Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Gene involved
SOD1
Mutation tested
c.118G>A
Transmission mode : Autosomal recessive
Publication : Awano et al. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis.
Gene involved
SOD1
Mutation tested
c.52A>T
(DM-sod1B)
Transmission mode : Autosomal recessive
Publication : Wininger et al. (2011). Degenerative myelopathy in a Bernese Mountain Dog with a novel SOD1 missense mutation.