Abnormal development and structure of the cerebellum
Symptoms Poor growth, muscle weakness, whole-body tremors, ataxia, tonic-clonic seizures, death usually occurs in first week of life
Gene involved ATF2
Mutation tested c.152T>G (NEWS)
Transmission mode : Autosomal recessive
Publication : Chen et al. (2008). A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2.