Chronic neurological disorder involving the loss of the brain's ability to regulate sleep-wake cycles normally
Symptoms Excessive daytime sleepiness, cataplexy (sudden loss of muscle tone without loss of consciousness) triggered by emotions
Gene involved HCRTR2
Mutation tested c.160G>A
Transmission mode : Autosomal recessive
Publication : Hungs et al. (2001). Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines.
Gene involved HCRTR2
Mutation tested c.1103+5G>A
Transmission mode : Autosomal recessive
Publication : Lin et al. (1999). The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.