Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs
Symptoms hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death
Gene involved MDR1
Mutation tested c.227_230delATAG (MDR1)
Transmission mode : Autosomal codominant
Publication : Mealley et al. (2001). Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.