Multidrug Sensitivity

Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs

hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death

Gene involved

Mutation tested
c.227_230delATAG (MDR1)

Transmission mode : Autosomal codominant

Publication : Mealley et al. (2001). Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.