MDR1 Multidrug Sensitivity

Abnormal function of a transport protein located in the blood-brain barrier leading to neurotoxicity after the intake of certain medicinal products

Dilated pupils, vomiting, tremors, locomotor difficulties, blindness, seizures, coma and eventually death of the animal.

Gene involved

Mutation tested

Transmission mode : Autosomal recessive
Age of onset : From birth

Publication : Mealey et al. (2015). Identification of a nonsense mutation in feline ABCB1.