Abnormal function of a transport protein located in the blood-brain barrier leading to neurotoxicity after the intake of certain medicinal products
Symptoms Dilated pupils, vomiting, tremors, locomotor difficulties, blindness, seizures, coma and eventually death of the animal.
Gene involved ABCB1
Mutation tested c.1930_1931delTC
Transmission mode : Autosomal recessive Age of onset : From birth
Publication : Mealey et al. (2015). Identification of a nonsense mutation in feline ABCB1.