Dermatosis characterized by poor growth, immune deficiency, and skin lesions, especially at the paws and in the face
Symptoms Skin lesions (erythema, tightly adherent scale with crust) at the feet, elbows, hocks and muzzle, failure to thrive, immunodeficiency, skin infections. Later on, hyperkeratosis of the footpads and degeneration of the nails. Affected puppies typically die before they reach an age of two years, either due to infections or euthanasia when their foot lesions become very severe and painful.
Gene involved MKLN1
Mutation tested c.400+3A>C
Transmission mode : Autosomal recessive
Publication : Bauer et al. (2018). MKLN1 splicing defect in dogs with lethal acrodermatitis.