Metabolic disorder resulting in elevated levels of uric acid in blood and urine. This trait predisposes dogs to form urate bladder stones
Symptoms Difficulty urinating, blood in urine, urinary incontinence, abdominal pain. Some complications are possible: acute kidney failure, urinary tract infection, or rupture of bladder. Predisposition to urate bladder stones caused by this mutation is variable according to breeds. Most of homozygous mutated dogs never show symptoms.
Gene involved SLC2A9
Mutation tested c.616G>T
Transmission mode : Autosomal recessive
Publication : Bannasch et al. (2008). Mutations in the SLC2A9 Gene Cause Hyperuricosuria and Hyperuricemia in the Dog.