Goniodysgenesis and Glaucoma

Gene involved
OLFML3

Mutation tested
c.590G>A

Transmission mode : Autosomal recessive

Publication : Pugh et al. (2019). Arginine to Glutamine variant in Olfactomedin Like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the Border Collie dog breed.
Oliver et al. (2020). A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom.

Concerned breeds :