Duchenne Muscular Dystrophy

Gene involved
DMD

Mutation tested
c.7293+5G>T

Transmission mode : X-linked recessive

Publication : Walmsley et al. (2010). A duchenne muscular dystrophy gene hot spot mutation in dystrophin-deficient Cavalier King Charles Spaniels is amenable to exon 51 skipping.

Gene involved
DMD

Mutation tested
c.6051-6057delTCTCAAT

Transmission mode : X-linked recessive

Publication : Nghiem et al. (2016). Whole genome sequencing reveals a 7 base-pair deletion in DMD exon 42 in a dog with muscular dystrophy.

Gene involved
DMD

Mutation tested
A>G intron 6 splice acceptor site (GRMD)

Transmission mode : X-linked recessive

Publication : Sharp et al. (1992). An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy.

Concerned breeds :

Gene involved
DMD

Mutation tested
2.2 Mb inversion (LRMD)

Transmission mode : X-linked recessive

Publication : Barthélémy et al. (2020). X-linked muscular dystrophy in a Labrador Retriever strain: phenotypic and molecular characterisation.