Degeneration of the cerebellum, caudate nucleus and substantia nigra resulting in nervous disorder
Symptoms Cranial intention tremor, goose-stepping gait (ataxia), falling episodes, severe and progressive movement disorder
Gene involved SERAC1
Mutation tested c.182+1_182+4delGTAA
Transmission mode : Autosomal recessive
Publication : Johnson et al. (2013). Canine Multiple System Degeneration is associated with distinct SERAC1 mutations in two different dog breeds.
Gene involved SERAC1
Mutation tested c.1536G>A
Transmission mode : Autosomal recessive
Publication : Johnson et al. (2013). Canine Multiple System Degeneration is associated with distinct SERAC1 mutations in two different dog breeds.