Autoimmune Lymphoproliferative Syndrome

Abnormal lymphocyte production leading to chronic, non-infectious and non-malignant lymphoproliferation

Rapidly progressive and significant enlargement of lymph nodes and spleen, weight loss, anorexia.

Gene involved

Mutation tested
c.413_414insA (ALPS)

Transmission mode : Autosomal recessive
Age of onset : Between 6 and 8 weeks old

Publication : Aberdein et al. (2016). A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats.

Concerned breeds :