Abnormal lymphocyte production leading to chronic, non-infectious and non-malignant lymphoproliferation
Symptoms Rapidly progressive and significant enlargement of lymph nodes and spleen, weight loss, anorexia.
Gene involved FASL
Mutation tested c.413_414insA (ALPS)
Transmission mode : Autosomal recessive Age of onset : Between 6 and 8 weeks old
Publication : Aberdein et al. (2016). A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats.